Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
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چکیده
منابع مشابه
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Functional expression of the K-Cl cotransporter KCC2 in developing central neurons is crucial for the maturation of Cl(-)-dependent, GABA(A) receptor-mediated inhibitory responses. In pyramidal neurons of the rodent hippocampus, GABAergic postsynaptic responses are typically depolarizing and often excitatory during the first postnatal week. Here, we show that a single neonatal seizure episode i...
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KCC2 is a neuron-specific potassium-chloride co-transporter controlling intracellular chloride homeostasis in mature and developing neurons. It is implicated in the regulation of neuronal migration, dendrites outgrowth and formation of the excitatory and inhibitory synaptic connections. The function of KCC2 is suppressed under several pathological conditions including neuronal trauma, different...
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2020
ISSN: 1756-6606
DOI: 10.1186/s13041-020-00689-z